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Medical disclaimer: This site provides comparison information only and does not constitute medical advice. Consult your GP for medical guidance. Clinical content reviewed by Nathanial Smith, Registered Healthcare Professional (HCPC reg. PA43353).

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Tests for low mood

Persistent low mood, anxiety, or emotional changes

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Why test for low mood?

While low mood and depression have complex causes, several treatable medical conditions can contribute. Thyroid dysfunction, vitamin D deficiency, iron deficiency anaemia, and hormonal imbalances are all known to affect mood, energy, and cognitive function. Blood testing can identify these physical contributors alongside other care.

Recommended tests

Thyroid function

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Both hypo- and hyperthyroidism can significantly affect mood and anxiety levels

TSH
Free T4
Free T3

Vitamin D

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Strong correlation between low vitamin D and mood disorders, especially in winter months

25-OH vitamin D

Hormone profile

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Testosterone, oestrogen, and cortisol imbalances can all impact emotional wellbeing

Testosterone
Oestradiol
Cortisol
DHEA-S

Full blood count

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Anaemia is a common but often overlooked contributor to low mood

Haemoglobin
Red blood cells
MCV

When to see your GP

If you are experiencing persistent low mood, thoughts of self-harm, or significant changes in sleep and appetite, please speak to your GP or contact the Samaritans (116 123) immediately.

Compare all low mood testsView all symptoms

Why test for low mood?

Symptom-led matching

See the tests commonly used to investigate this symptom

UKAS accredited labs

Every listed provider uses UKAS-accredited UK laboratories

Clear turnaround

Typical result times shown alongside price and biomarker coverage

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